重組人內(nèi)皮素2重組蛋白，HIS標(biāo)簽(EDN2)說明
目錄編號(hào)：HOR-006
中文名稱：重組人內(nèi)皮素2重組蛋白，HIS標(biāo)簽EDN2
英文名稱：Recombinant Human Endothelin-2, His
重組人內(nèi)皮素2重組蛋白，HIS標(biāo)簽序列號(hào):
MGSSHHHHHH SSGLVPRGSH MGSQAAATLE QPASSSHAQG THLRLRRCSC SSWLDKECVY FCHL DIIWVN TPEQTAPYGL GNPPRRRRRS LPRRCQCSSA RDPACATFCL RRPWTEAGAV PSRKSPAD VF QTGKTGATTG ELLQRLRDIS TVKSLFAKRQ QEAMREPRST HSRWRKR.
重組人內(nèi)皮素2重組蛋白，HIS標(biāo)簽(EDN2)簡介: EDN2 Human Recombinant produced in E.Coli is a single， non-glycosylated polypeptide chain containing 177 amino acids （25-178 a.a.） and having a molecular mass of 19.9kDa. EDN2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
重組人內(nèi)皮素2重組蛋白，HIS標(biāo)簽(EDN2)背景: Endothelin-2 is a Hypoxia-induced Autocrine Survival Factor for Breast Tumor Cells. The synthesis of EDN2 by human kidney carcinoma cells is decreased by EGF. EDN2 is a chemoattractant for macrophages and THP-1 monocytic cells. Chemotaxis towards EDN2 is via the MAPK pathway: p44 and p42 are phosphorylated when THP-1 cells are stimulated with EDN2. Migration to EDN2 is inhibited by hypoxia and by pertussis toxin. EDN2 leads to activation of macrophages. EDN2 shares a similar peptide sequence with chemokines and may signal via a similar receptor and MAPK-mediated pathway. Furthermore， EDN2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia.
來源宿主：大腸桿菌中重組表達(dá).
產(chǎn)品規(guī)格：
溶解建議：
提供的重組人內(nèi)皮素2重組蛋白，HIS標(biāo)簽產(chǎn)品為無菌的無色溶液.
穩(wěn)定性說明：
人內(nèi)皮素2蛋白，HIS標(biāo)簽產(chǎn)品建議保存于4℃時(shí)，應(yīng)在2-4周內(nèi)用完.冰凍于-20℃可保存更長時(shí)間.長期保存，推薦添加載體蛋白（0.1% HSA or BSA）.請避免反復(fù)凍融.
重組人內(nèi)皮素2重組蛋白，HIS標(biāo)簽(EDN2)具體請咨詢在線客服，或者來電索要詳細(xì)說明書！
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