人內(nèi)皮素1(EDN1)說明
目錄編號(hào)：HOR-307
中文名稱：人內(nèi)皮素1(EDN1)
英文名稱：Human Endothelin-1
人內(nèi)皮素1(EDN1)序列號(hào):
Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-As p-Ile-Ile-Trp.
人內(nèi)皮素1(EDN1)簡介:
EDN1 contains 21 amino acids having a molecular mass of 2491.95 Dalton.
人內(nèi)皮素1(EDN1)背景:
EDN1 is a powerful mitogen mediator of smooth muscle tone， and inflammatory regulator that is involved in diseases of the airways， pulmonary circulation， and inflammatory lung diseases， both acute and chronic. Endothelin-2 and Endothelin-3 vary from Endothelin-1 by two and six amino acids， respectively， and share homology， particularly at the carboxy terminus with sarafotoxins a-e. The lung has the largest levels of EDN1 secreted by endothelium， smooth muscle， airway epithelium， and a diversity of other cells. ET-1 also circulates in the plasma. Endothelin-1 along with endothelin-2， & endothelin-3 （ET-3） consist of the endothelin family of 21 amino acid peptides manufactured in a variety of cells and tissues， particularly endothelial and epithelial lineages. These endothelins are derivatives from three genes. The endothelins are normally connected with hypertension， though they regulate a diversity of other effects through two G-protein coupled receptors， ET-A and ET-B. The endothelins are derivatives from a precursor peptides using cleavage by metalloproteases for instance endothelin-converting enzymes.
來源宿主：
產(chǎn)品規(guī)格：
溶解建議：
提供的人內(nèi)皮素1產(chǎn)品為白色無菌凍干粉末，凍干粉里不含有其它添加劑.推薦使用無菌的18MΩ的超純水來溶解，濃度不低于100ug/ml，便于后續(xù)稀釋.
穩(wěn)定性說明：
Lyophilized EDN1 although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution EDN1 should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
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