重組人甲狀旁腺素（1-34）(PTH (1-34))說明
目錄編號(hào)：HOR-281
中文名稱：重組人甲狀旁腺素（1-34）
英文名稱：Recombinant Human Parathyroid Hormone (1-34)
重組人甲狀旁腺素（1-34）序列號(hào):
The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Val-Ser-Glu-Ile. The amino acid composition is as follows: Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe.
重組人甲狀旁腺素（1-34）(PTH (1-34))簡介: Parathyroid Hormone Human Recombinant （C181H290N55O51S2） produced in E.Coli is a single， non-glycosylated， polypeptide chain containing 34 amino acids and having a molecular mass of 4117.8 Dalton. The PTH is purified by proprietary chromatographic techniques.
重組人甲狀旁腺素（1-34）(PTH (1-34))背景: Parathyroid hormone （PTH）， or parathormone， is secreted by the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calciumin the blood， whereas calcitonin （a hormone produced by the parafollicular cells of the thyroid gland） acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon parathyroid hormone receptorin three parts of the body: In the bones- It enhances the release of calcium from the large reservoir contained in the bones. Bone resorption is the normal destruction of bone by osteoclasts， which are indirectly stimulated by PTH. Stimulation is indirect since osteoclasts do not have a receptor for PTH； rather， PTH binds to osteoblasts， the cells responsible for creating bone. Binding stimulates osteoblasts to increase their expression of RANKL， which can bind to osteoclast precursors containing RANK， a receptor for RANKL. The binding of RANKL to RANK stimulates these precursors to fuse， forming new osteoclasts which ultimately enhances the resorption of bone.
來源宿主：大腸桿菌中重組表達(dá).
產(chǎn)品規(guī)格：
溶解建議：
提供的重組人甲狀旁腺素（1-34）產(chǎn)品為白色無菌凍干粉末，推薦使用無菌的18MΩ的超純水來溶解，濃度不低于100ug/ml，便于后續(xù)稀釋.
穩(wěn)定性說明：
Lyophilized Parathyrin although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution PTH should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
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